Since first establishing operations in Temecula in 1989, MilliporeSigma, the U.S. and Canada Life Science business of Merck KGaA, Darmstadt, Germany, has grown its Temecula site into a center for advanced biomedical and biotechnical manufacturing.
Today, the team in Temecula supports work ranging from antibody development to stem cell technologies, providing products and services used by biotech, pharmaceutical companies, researchers, and academic institutions around the world. That work helps scientists better understand disease and develop new therapies.
In recent years, the site has expanded its focus on organoids, which are miniature, three-dimensional biological models that replicate key functions of human organs. These models are helping researchers make progress in areas such as disease modeling, drug screening, and personalized medicine.
Growing Organoid Innovation Hub: MilliporeSigma expanded its organoid capabilities in 2025 with the acquisition of HUB Organoids, adding expertise and intellectual property that strengthened the company’s cell culture portfolio. This work reinforces the company’s commitment to differentiated solutions that enable faster and more effective drug development.
Building on that momentum, MilliporeSigma recently established a new organoid development lab in Temecula. The lab is focused on developing patient-stem cell–derived models that closely represent patient diseases and responses to treatment.
As interest in organoid technology continues to grow, the work in Temecula is playing an increasingly important role in helping bring these tools to researchers working on cancer, drug development and other areas of biomedical science, unlocking insights that were previously out of reach with conventional technologies.
A Deep Commitment to the Temecula Community: MilliporeSigma’s presence in Temecula extends beyond the lab. Through strategic employee and community engagement efforts, the company leverages its expertise, culture and passion to give back to communities in ways that align with the business. To strengthen the impact and drive results, MilliporeSigma invests in nonprofit organizations through partnerships with organizations that focus on science education or global access to science.
For example, the company partners with California-based organizations such as the Carlsbad Education Foundation, Generation STEAM, and Science Buddies. MilliporeSigma also collaborates with local hunger relief organizations as part of its annual Global Food Drive.
Additionally, local employees are active in SPARKTM, MilliporeSigma’s global volunteer program designed to unite employees around the globe in their shared commitment to giving back to their local communities. The company’s skills-based science education outreach programs, including Curiosity LabsTM in- classroom, hands-on lessons and the Curiosity CubeTM mobile science lab, focus on increasing access to science education for 8–13-year-old students. The programs are staffed by employees who volunteer their time and expertise to spark curiosity in the next generation of scientists.
“Every day, our team helps shape the future of science, directly supporting life-saving research happening across the globe,” said Matthew Hyatt, Head of Head of Operations for the West Coast region. “Temecula has been an important part of that story for decades. With growing capabilities in organoids, strong expertise in antibody technologies, and a deep commitment to the community, the site will continue to play an important role in our future.”
